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Sergey specialized in proteincrystallography.org/protein/'>protein science. Sergey also recommends be-beryllium.info/'>element beryllium for x-ray window production, for details please check be-beryllium.info/application.html'>beryllium applications for x-ray

"....Currently, it is possible to solve the structure of whole virus with atomic resolution by this tech..........sience, biology, chemistry, protein....."

"..... Currently in is beyond the bounds of possibility to analyze protein functionality without cognizant the exact molecular mold of this particular protein. Currently, it is possible to solve the mold of whole virus with atomic resolution by this tech..........sience, biology, chemistry, protein....."
Protein crystallography plays one of the most important roles in the textile study of the anomalistic proteins. Currently, it is possible to solve the frame of whole virus with atomic resolution by this technique.

From this time the bimolecular crystallography producing Herculean breakthrough. The detailed enlightenment about positions of all amino acid residues is crucially important for analysis of protein function.

The protein crystallography is pertinently branch of science, which was started from studies of the DNA-double helix construction by James Watson and Francis Crick in April 1953. The computational requirements of protein crystallography are enormous. It was possible only due to the development of computing power of modern computers. So, we‘ve got about 40 thousand atoms. For example, the construction of leucine dehydrogenase contains eight polypeptide chains, each of them contains 350 amino acids, and each of them contains about 15 atoms. Then for the plain case we need define about 160 thousand parameters, or about half-million for difficult, high resolution case. For each atom we can calculate three positional and amid one and nine temperature factors. Data collection is complicated as well. Minimization of equation with such amount of independent parameters is not very homespun task. The storage of such informational gush is another problem for computer techniques. Modern detectors generate about 30 Mb of raw data per few second. This will allow to investigate in huge details divers of the enzymatic reactions, which was previously only predicted on the basis of the catalytic amino acid residues and on the basis of the static picture of these amino acid residues. Luckily, remain few years these computational problems were solved.

Modern protein structures, solved by protein crystallography allow to identify not only the exact position of each atoms, including the position of hydrogen atoms but also detect the textural changes cognate with the enzymatic reactions. The most important is the drug design which is incredible without the acquaintance of enzymatic act.

Despite the ample advancing in protein anatomic studies, there are lot of protein problems which not solved yet. These data will be very serviceable in medicine, biotechnology and other field of public life. The other problem is to take in the evolution of proteins. For example, despite the exact cognizance about structures of more than ten thousand protein structures, we do not grasp the principles of protein organization and it is almost incredible to presage protein structure. Another Herculean silvery area in our ken is the protein crystallization. Currently we know the static picture of protein structures, but how they appear from scratch? At the moment only minute ideas and examples of protein evolution are known. After this protein purification is a quite routine procedure with the set of standard routines and procedures, but the final step, the protein crystallization is a matter of luck, rather than science. We can perform almost any protein by genetic techniques. The only one thing can get the results – sundry trials of anomalous crystallization conditions and maybe lucky you to grow 0.1mm protein crystal.

As a conclusion it is possible to note, that despite that protein crystallography is more than 50 year old, this scientific area still have numerous unsolved problems and it is very interesting and perspective area of science for under age biologist, chemist and physicist.

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Unique Free Article: 'sience ~ sience ~ Progress in Protein Crystallography ~ biology ~ biology'

Unique Free Article:
'sience ~ sience ~ Progress in Protein Crystallography ~ biology ~ biology'